ORC3 and MCM10

Data Source:
HPRD (in vitro)

		ORC3	MCM10
Description		origin recognition complex subunit 3	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Nuclear Body DNA Replication Preinitiation Complex	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	DNA Replication Origin Binding Protein Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication Neural Precursor Cell Proliferation	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Nicotine dependence symptom count ( 25555482)
Interacting Genes		21 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 DBF4 FBXO7 H3-4 H4-16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		23595	55388
HPRD ID		05398	11297
Ensembl ID		ENSG00000135336	ENSG00000065328
Uniprot IDs		Q9UBD5	Q7L590
PDB IDs		5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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