MCM10 and KLHL40

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MCM10	KLHL40
Description		minichromosome maintenance 10 replication initiation factor	kelch like family member 40
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band
	Molecular Function	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Nicotine dependence symptom count ( 25555482)
Interacting Genes		38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A	13 interacting genes: AHNAK C7orf31 CC2D1B FSD2 LMOD3 LRRC29 MCM10 REL SAXO1 TASOR2 VDAC1 ZBED1 ZNF451
Entrez ID		55388	131377
HPRD ID		11297	11058
Ensembl ID		ENSG00000065328	ENSG00000157119
Uniprot IDs		Q7L590	A8K5H9 Q2TBA0
PDB IDs			4ASC
Enriched GO Terms of Interacting Partners?
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