ORC3 and CDC45

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ORC3	CDC45
Description		origin recognition complex subunit 3	cell division cycle 45
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleoplasm Nuclear Pre-replicative Complex Nuclear Origin Of Replication Recognition Complex Nuclear Body DNA Replication Preinitiation Complex	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	DNA Replication Origin Binding Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication Neural Precursor Cell Proliferation	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		21 interacting genes: APP CCNE2 CDC45 CDC6 CDK4 DBF4 FBXO7 H3-4 H4-16 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 SUMO2 TERF2 USP2	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		23595	8318
HPRD ID		05398	09145
Ensembl ID		ENSG00000135336	ENSG00000093009
Uniprot IDs		Q9UBD5	O75419
PDB IDs		5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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