DDAH2 and MAP3K20

Data Source:
BioGRID (two hybrid)

		DDAH2	MAP3K20
Description		dimethylarginine dimethylaminohydrolase 2	mitogen-activated protein kinase kinase kinase 20
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Citrulline Metabolic Process Arginine Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity	DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Cytoskeleton Organization Cell Cycle Arrest Activation Of JUN Kinase Activity Cell Death Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint
Pathways		eNOS activation
Drugs		Citrulline	Dasatinib Fostamatinib
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14	32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775
Entrez ID		23564	51776
HPRD ID		09204	11791
Ensembl ID		ENSG00000213722	ENSG00000091436
Uniprot IDs		O95865 V9HW53	D4Q8H0 Q9NYL2
PDB IDs			5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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