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WBP2 and YAP1
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro)
WBP2
YAP1
Description
WW domain binding protein 2
Yes1 associated transcriptional regulator
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
TEAD-YAP Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Activity
Protein Binding
Estrogen Receptor Binding
Chromatin DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Proline-rich Region Binding
DNA-binding Transcription Factor Binding
Biological Process
Response To Progesterone
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Response To Estrogen
Establishment Of Protein Localization
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Progesterone Receptor Signaling Pathway
Cellular Response To Estrogen Stimulus
Positive Regulation Of Histone H3-K14 Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Trophectodermal Cell Differentiation
Tissue Homeostasis
Heart Process
Embryonic Heart Tube Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Notochord Development
Response To Progesterone
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Hippo Signaling
Wound Healing
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Lateral Mesoderm Development
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Progesterone Receptor Signaling Pathway
Positive Regulation Of Cardiac Muscle Cell Proliferation
Contact Inhibition
Bud Elongation Involved In Lung Branching
Lung Epithelial Cell Differentiation
Intestinal Epithelial Cell Development
Cardiac Muscle Tissue Regeneration
Protein-containing Complex Assembly
Interleukin-6-mediated Signaling Pathway
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Platelet count (
32888494
)
Red blood cell count (
32888494
)
White matter hyperintensities (
32358547
)
Cleft palate (
27018472
)
Colorectal cancer or advanced adenoma (
30510241
)
Heel bone mineral density (
30598549
)
Migraine (
27322543
)
Offspring birth weight (
31043758
)
Polycystic ovary syndrome (
22885925
30566500
26416764
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Pulse pressure (
30224653
30578418
)
Reticulocyte count (
32888494
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
54 interacting genes:
ANAPC1
ANKRD13A
ANKRD13D
ARCN1
BAG3
CCT7
CLEC4G
COPA
COPB1
COPB2
COPE
COPG1
CUEDC1
DDX17
EEF1B2
EPN2
ESR1
GRPEL1
H4C1
HOMER3
HUWE1
ITCH
KRT18
KRT8
KRT9
LGALS8
MAGEA4
MAGI1
MYO6
NEDD4
NEDD4L
PAX8
POLH
RHBDD3
RNF168
RPS27A
RPS3
SDHA
SEPTIN3
SMAD5
TDP2
TOLLIP
TOM1L2
UBA52
UBC
UBE2D3
UBE2E3
UBE3A
UBQLN1
UIMC1
WWP1
WWP2
WWTR1
YAP1
33 interacting genes:
ABL1
AKT1
ENAH
ERBB4
GAS5
HNRNPU
KIF5A
LINC00839
NFE2
OTUD1
PRRG2
PTCH1
PTEN
PTPN21
RUNX1
RUNX2
RUNX3
SCAMP3
SLC9A3R1
SMAD1
SMAD7
SUMO3
TEAD1
TEAD2
TEAD3
TEAD4
TP53BP2
TP73
WBP1
WBP2
YWHAG
YWHAQ
YWHAZ
Entrez ID
23558
10413
HPRD ID
06097
09424
Ensembl ID
ENSG00000132471
ENSG00000137693
Uniprot IDs
A0A024R8L1
Q969T9
A0A024R3E4
K0KVU2
P46937
Q86T74
PDB IDs
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
4RE1
4REX
5OAQ
5YDX
5YDY
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GE3
6GE4
6GE5
6GE6
6GEC
6GEE
6GEG
6GEI
6GEK
6HIK
6HIL
6Q2X
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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