MORC3 and SUMO3

Data Source:
BioGRID (two hybrid)

		MORC3	SUMO3
Description		MORC family CW-type zinc finger 3	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nucleoplasm Nuclear Matrix PML Body	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Methylated Histone Binding	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Protein Phosphorylation Cell Aging Post-embryonic Development Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Fibroblast Proliferation Protein Stabilization Maintenance Of Protein Location In Nucleus	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways			SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 31562340)	Delirium ( 29631748)
Interacting Genes		5 interacting genes: ERCC6 KPNA2 RNF216 SUMO2 UBC	53 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496
Entrez ID		23515	6612
HPRD ID		10316	03754
Ensembl ID		ENSG00000159256	ENSG00000184900
Uniprot IDs		B4DHJ4 Q14149 Q4VBZ9	P55854
PDB IDs		4QQ4 5SVI 5SVX 5SVY 6O1E 6O5W	1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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