SF3B1 and MIR1-1

Data Source:
BioGRID (unspecified method)

		SF3B1	MIR1-1
Description		splicing factor 3b subunit 1	microRNA 1-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Extracellular Space
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	RNA Polymerase II Complex Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity By Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		H3B-8800
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		100 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DUX4 DYRK1A ERG IL7R MELK MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC NUDT21 PHF5A PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 SUMO2 TCERG1 TOP1 U2AF2 WBP4	89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		23451	406904
HPRD ID		09281
Ensembl ID		ENSG00000115524	ENSG00000199017
Uniprot IDs		B4DGZ4 O75533
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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