SLC7A8 and MFF

Data Source:
BioGRID (two hybrid)

		SLC7A8	MFF
Description		solute carrier family 7 member 8	mitochondrial fission factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane	Mitochondrion Mitochondrial Outer Membrane Peroxisome Synaptic Vesicle Integral Component Of Mitochondrial Outer Membrane Integral Component Of Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Binding Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity Glycine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Peptide Antigen Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Amino Acid Transmembrane Transport Amino Acid Transport Response To Toxic Substance Organic Cation Transport Neutral Amino Acid Transport Glycine Transport Leucine Transport Tryptophan Transport Valine Transport Proline Transmembrane Transport Leukocyte Migration Metal Ion Homeostasis Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Leucine Import Across Plasma Membrane Transport Across Blood-brain Barrier Toxin Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Mitochondrial Fission Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Mitochondrial Fragmentation Involved In Apoptotic Process Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Targeting To Membrane Regulation Of Peroxisome Organization
Pathways		Basigin interactions Amino acid transport across the plasma membrane
Drugs		Phenylalanine Alanine
Diseases
GWAS			Intraocular pressure ( 29617998) Refractive astigmatism ( 30306274)
Interacting Genes		26 interacting genes: ABHD16A AGPAT4 AQP6 COMT DERL1 FXYD6-FXYD2 MFF MFSD3 NDUFA3 NINJ2 REEP4 SIGLEC5 SLC25A46 SLC30A2 SLC3A1 SLC3A2 SMPD2 SNORC SYCE1L SYNJ2BP TMEM14B TMEM208 TMEM60 TMEM65 YIPF1 YIPF6	105 interacting genes: ADIPOQ AGPAT4 AIG1 ANKRD46 APOD APOL2 AQP3 AQP6 ATP6V0B BET1 C14orf180 C1QL4 C3orf52 CD79A CDIPT CEND1 CLDN19 CMTM5 CNIH1 COL4A5 CTXN3 CXCL16 CYB5B CYBC1 DNM1L ERGIC3 FAM209A FAM210B FAM3C FATE1 FCER1G FDCSP FXYD6 GJB1 GKN1 GOSR2 GPR152 IGFBP5 JAGN1 LAT LHFPL5 LPAR3 MEOX2 MIP MMGT1 MOSPD3 MPZL1 MTNR1B NIPAL3 NRM NTS OPN1SW OPRM1 PLK3 PLLP PLN PLP1 RAET1L RETREG3 RHBDL1 SACM1L SEC11C SEC22A SEC22B SEC23A SERINC2 SHISAL1 SLC18A3 SLC35B1 SLC41A2 SLC7A1 SLC7A14 SLC7A8 SMIM1 STRIT1 STX7 STX8 TEX264 TFRC TM6SF1 TMEM128 TMEM140 TMEM14C TMEM201 TMEM218 TMEM229B TMEM237 TMEM254 TMEM42 TMEM60 TMEM86B TMEM88 TMEM97 TMX2 TRAF3IP3 TRAM1L1 TRARG1 TSPAN2 TSPAN33 TSPO2 UNC50 UNC93B1 UPK1B VAMP4 ZFPL1
Entrez ID		23428	56947
HPRD ID		11971	16653
Ensembl ID		ENSG00000092068	ENSG00000168958
Uniprot IDs		Q53EM9 Q9UHI5	A0A0A0MS29 A1MAC2 Q9GZY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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