GALNT13 and EXOSC2

Data Source:
BioGRID (two hybrid)

		GALNT13	EXOSC2
Description		polypeptide N-acetylgalactosaminyltransferase 13	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	O-glycan Processing Protein Phosphopantetheinylation Protein O-linked Glycosylation Via Serine Protein O-linked Glycosylation Via Threonine	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		O-linked glycosylation of mucins	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Aging traits ( 17903295) Blood trace element (Zn levels) ( 23720494) Body mass index ( 24348519) Coronary artery disease in type 1 diabetes ( 29695241) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Liver enzyme levels (alanine transaminase) ( 24124411) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Placental abruption ( 29884306) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Schizophrenia or schizoaffective disorder ( 31591465) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		2 interacting genes: EXOSC2 SKIV2L	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		114805	23404
HPRD ID		16325	03758
Ensembl ID		ENSG00000144278	ENSG00000130713
Uniprot IDs		B3KY85 Q8IUC8	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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