EGFR and PPARG

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		EGFR	PPARG
Description		epidermal growth factor receptor	peroxisome proliferator activated receptor gamma
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Junction Endocytic Vesicle Clathrin-coated Vesicle Membrane Early Endosome Membrane Nuclear Membrane Protein-containing Complex Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen	Chromatin Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle Receptor Complex Perinuclear Region Of Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Virus Receptor Activity Chromatin Binding Double-stranded DNA Binding MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor-activated Receptor Activity Integrin Binding Protein Binding Calmodulin Binding ATP Binding Enzyme Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding Nitric-oxide Synthase Regulator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Epidermal Growth Factor Binding Actin Filament Binding ATPase Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Prostaglandin Receptor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Phosphatase Binding Estrogen Receptor Binding Activating Transcription Factor Binding Peptide Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Retinoid X Receptor Binding Arachidonic Acid Binding DNA Binding Domain Binding LBD Domain Binding Alpha-actinin Binding E-box Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Ossification Positive Regulation Of Protein Phosphorylation Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Translation Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Multicellular Organism Development Midgut Development Learning Or Memory Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nitric Oxide Mediated Signal Transduction Magnesium Ion Homeostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Diterpenoid Metabolic Process Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Response To Cobalamin Response To Hydroxyisoflavone Positive Regulation Of Kinase Activity Cellular Response To Reactive Oxygen Species Cellular Response To Drug Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Ovulation Cycle Hydrogen Peroxide Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Tongue Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Viral Entry Into Host Cell Protein Autophosphorylation Astrocyte Activation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Nitric-oxide Synthase Activity Protein Insertion Into Membrane Response To Calcium Ion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Response To UV-A Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Cell-cell Adhesion Positive Regulation Of Protein Kinase C Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Prolactin Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Cardiocyte Differentiation Regulation Of Cell Motility	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Negative Regulation Of Acute Inflammatory Response Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Heart Development Response To Nutrient Regulation Of Blood Pressure Response To Cold Response To Mechanical Stimulus Hormone-mediated Signaling Pathway Macrophage Derived Foam Cell Differentiation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Long-chain Fatty Acid Transport Negative Regulation Of Angiogenesis Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Cell Differentiation Monocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of BMP Signaling Pathway Epithelial Cell Differentiation Response To Caffeine Animal Organ Regeneration Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Response To Immobilization Stress Response To Drug Glucose Homeostasis Response To Starvation Regulation Of Circadian Rhythm Lipoprotein Transport Positive Regulation Of DNA Binding Negative Regulation Of Blood Vessel Endothelial Cell Migration Response To Estrogen Innate Immune Response Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Retinoic Acid Receptor Signaling Pathway Cell Maturation Rhythmic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response White Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Telomerase Activity Lipid Homeostasis Positive Regulation Of Phagocytosis, Engulfment Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Cholesterol Transporter Activity Negative Regulation Of Gene Silencing By MiRNA Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Prostaglandin E Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hyperoxia Response To Metformin Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Signaling Receptor Activity
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Regulation of PTEN gene transcription Regulation of PTEN gene transcription MECP2 regulates transcription factors
Drugs		Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib	alpha-Linolenic acid Icosapent Troglitazone Mesalazine Valproic acid Indomethacin Rosiglitazone Fenoprofen Nateglinide Sulfasalazine Clofazimine Repaglinide Telmisartan Balsalazide Ibuprofen Glipizide Amiodarone Pioglitazone Mitiglinide Bezafibrate Flufenamic acid Resveratrol Phthalic Acid Capric acid Doconexent Oleic Acid (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID Reglitazar Elafibranor AMG-131 CLX-0921 Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid 9(S)-HODE difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID 3-(5-methoxy-1H-indol-3-yl)propanoic acid Indeglitazar (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid 2-chloro-5-nitro-N-phenylbenzamide (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE Triclosan (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid Aleglitazar Clinofibrate Cannabidiol Lobeglitazone Ciglitazone Dexibuprofen Omega-3 fatty acids Curcumin Arhalofenate Isoflavone Naveglitazar Fenofibric acid Fish oil Medical Cannabis Nabiximols Darglitazone Curcumin sulfate
Diseases		Choriocarcinoma Gastric cancer Bladder cancer Oral cancer Glioma Laryngeal cancer Cervical cancer Esophageal cancer	Type II diabetes mellitus Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Thyroid cancer
GWAS		Dental caries (decayed and filled deciduous teeth) ( 31533690) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 29743610) Impulsivity ( 30718321) Initial alcohol sensitivity ( 30276832) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-glioblastoma glioma ( 28346443) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Refractive astigmatism ( 30306274) Subjective response to lithium treatment ( 26503763)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Arterial stiffness index ( 31235810) Body mass index ( 28892062 25673413 29273807) Cholesterol, total ( 25961943) Drug-induced liver injury ( 22968431) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fasting blood insulin ( 25631608) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29403010) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 25673412) Idiopathic osteonecrosis of the femoral head ( 31135556) LDL cholesterol ( 25961943) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (thyroid preparations) ( 31015401) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Neutrophil percentage of granulocytes ( 27863252) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Platelet count ( 29403010) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Potassium levels ( 29403010) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Sexual dimorphism in anthropometric traits ( 23754948) Systemic lupus erythematosus ( 28714469) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 22885922 18372903 24509480 30054458 29358691 30297969 29632382 31118516 32499647 20581827 17463246 30718926 17463248 17463249 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference ( 31453325) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		409 interacting genes: ABL2 ACTA1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM ALDOA AMH ANKS1A ANKS1B ANXA1 AOPEP AP2B1 APBA3 APBB1 APBB3 APP APPL1 AR AREG ARF4 ARHGEF12 ARHGEF7 ARRB2 ATIC ATP1A1 ATP1B1 ATP5F1C AXL B4GALT1 BAIAP2 BCAR3 BLK BLNK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CCDC88A CD44 CD59 CD82 CDC25A CDC34 CDH1 CDH5 CDK1 CEACAM1 CEBPB CEND1 CFL1 CLNK CLTA CLTCL1 CMTM8 CNOT9 CNTN2 COL9A3 CRK CSRP1 CTNNB1 CTNND1 CTTN CYLC2 DCBLD2 DCN DCTN2 DEGS1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP19 DUSP3 DYNC1H1 EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FANCC FAS FBXO25 FER FES FGR FKBP4 FKBP8 FN1 FRAT2 FRK GAB1 GABARAPL2 GAPDH GGA1 GGA3 GJB1 GNAI2 GNAS GOT1 GPM6B GPNMB GRAP2 GRB10 GRB14 GRB2 GRB7 GRIN2B GRK2 H3-4 HBEGF HCK HDAC6 HDAC7 HEMGN HEXIM1 HGS HOXC10 HPN HSH2D HSP90AA1 HSP90AB1 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 IKBKG IL13RA2 IL5RA ILKAP INPPL1 IQGAP1 IRS1 IRS4 ITGA5 ITGB1 ITGB2 ITK ITSN2 JAK2 JUP KCTD9P2 KEAP1 KRT17 KRT18 KRT7 KRT8 LAT LCK LCP2 LINC01139 LRP1 LRRK1 LYN MAP2K1 MAP3K12 MAP3K14 MAP3K3 MAP4K1 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 MAPT MAST1 MATR3 MDH1 MEGF6 MET MGARP MIF MOB4 MT-CO2 MTDH MUC1 MUC4 NANS NCAM1 NCK1 NCK2 NDN NEDD4 NF2 NIBAN2 NR3C1 NRG1 NTRK2 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRA PDGFRB PDK3 PDP1 PFKP PIK3C2A PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PIM1 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPARG PPM1A PPM1B PPP2CB PPP3CB PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKCE PRKCZ PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN18 PTPN2 PTPN20 PTPN22 PTPN6 PTPN7 PTPRB PTPRH PTPRJ PTPRR PTPRS PTPRT PTPRU RAB31 RAB3A RAF1 RAP1GDS1 RAPGEF1 RASA1 RGS16 RGS2 RGS4 RIN1 RIN2 RIPK1 RNF115 RNF126 RNF144A RRAD RUSC2 S100A4 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SELENOP SFN SGSM2 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BGRL3 SH3GL3 SHB SHC1 SHC2 SHC3 SHC4 SHD SHE SLA SLA2 SLC3A2 SLC9A3R1 SMURF2 SNCA SNRPD2 SNX1 SNX2 SNX4 SNX6 SNX9 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAP1 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B STIP1 STX17 STYX SUPT6H SYK TAB1 TEC TGFA TGFB1 TJP1 TLN1 TLR2 TMCO3 TNC TNFRSF1A TNK2 TNS1 TNS2 TNS3 TNS4 TPI1 TPM1 TRAF2 TRMO TRPV1 TSTD2 TUBA1A TUBA4A TXK TXN UBB UBE2V2 UCHL1 UROD VAPA VAV1 VAV2 VAV3 WASF3 WASL XRCC6 YES1 YWHAB YWHAQ YWHAZ ZAP70 ZNF510 ZPR1	115 interacting genes: ADCY4 ALOX15B ANP32A APP BCAS2 BRD8 CDC34 CDK5 CEP350 CNOT1 COPS5 CREBBP DNTTIP2 EDF1 EGFR EP300 ESRRA FABP1 FHOD1 FOXO1 GADD45B GADD45G GATA5 GRIP1 HDAC1 HDAC3 HDAC4 HELZ2 HMGA1 IGFBP3 IKBKB JAZF1 JMJD1C JUN JUND KAT2A KAT5 KCTD13 KIF11 KIF1A KLF5 LMO4 LRIF1 MAFF MAP2K1 MAPK1 MAPK8 MAPK9 MED1 MED24 MFHAS1 MIF4GD MSX2 MUC1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFE2L2 NFE2L3 NFKB1 NFKBIB NR0B1 NR0B2 NR1H2 NR1H3 NR2E3 NR4A1 NR4A2 NRIP1 NSD1 PAK4 PDIA2 PHB2 PML POU1F1 PPARGC1A PPM1B PRKCA RAD54L2 RANBP9 RARA RB1 RELA ROBO4 RXRA RXRB RXRG SERPINH1 SFPQ SIRT1 SMARCD3 SRSF1 STAT6 STUB1 SVIL SYT1 TFAP2A TNP1 TRIM24 TRIP4 UBC UBE2I USP7 VDR ZBTB20 ZBTB3 ZBTB5 ZBTB9 ZNF496 ZNHIT3 ZSCAN1
Entrez ID		1956	5468
HPRD ID		00579	03288
Ensembl ID		ENSG00000146648	ENSG00000132170
Uniprot IDs		B7Z2I3 E7BSV0 E9PFD7 F2YGG7 P00533 Q504U8	A0A494C1F9 D2KUA6 E9PFV2 E9PFX5 P37231
PDB IDs		1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M0B 2M20 2N5S 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0 4LQM 4LRM 4R3P 4R3R 4R5S 4RIW 4RIX 4RIY 4RJ4 4RJ5 4RJ6 4RJ7 4RJ8 4TKS 4UIP 4UV7 4WD5 4WKQ 4WRG 4ZAU 4ZJV 4ZSE 5C8K 5C8M 5C8N 5CAL 5CAN 5CAO 5CAP 5CAQ 5CAS 5CAU 5CAV 5CNN 5CNO 5CZH 5CZI 5D41 5EDP 5EDQ 5EDR 5EM5 5EM6 5EM7 5EM8 5FED 5FEE 5FEQ 5GMP 5GNK 5GTY 5GTZ 5HCX 5HCY 5HCZ 5HG5 5HG7 5HG8 5HG9 5HIB 5HIC 5J9Y 5J9Z 5JEB 5LV6 5SX4 5SX5 5U8L 5UG8 5UG9 5UGA 5UGB 5UGC 5UWD 5WB7 5WB8 5X26 5X27 5X28 5X2A 5X2C 5X2F 5X2K 5XDK 5XDL 5XGM 5XGN 5XWD 5Y25 5Y9T 5YU9 5ZTO 5ZWJ 6ARU 6B3S 6D8E 6DUK 6JRJ 6JRK 6JRX 6JWL 6JX0 6JX4 6JXT 6JZ0 6LUB 6LUD 6P1D 6P1L 6P8Q 6S89 6S8A 6S9B 6S9C 6S9D 6TFU 6TFV 6TFW 6TFY 6TFZ 6TG0 6TG1 6V5N 6V5P 6V66 6V6K 6V6O 6VH4 6VHN 6VHP	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 3WJ4 3WJ5 3WMH 3X1H 3X1I 4A4V 4A4W 4CI5 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4HEE 4JAZ 4JL4 4L96 4L98 4O8F 4OJ4 4PRG 4PVU 4PWL 4R06 4R2U 4R6S 4XLD 4XTA 4XUH 4XUM 4Y29 4YT1 5AZV 5DSH 5DV3 5DV6 5DV8 5DVC 5DWL 5F9B 5GTN 5GTO 5GTP 5HZC 5JI0 5LSG 5TTO 5TWO 5U5L 5UGM 5WQX 5WR0 5WR1 5Y2O 5Y2T 5YCN 5YCP 5Z5S 5Z6S 6AD9 6AN1 6AUG 6AVI 6C1I 6C5Q 6C5T 6D3E 6D8X 6D94 6DBH 6DCU 6DGL 6DGO 6DGP 6DGQ 6DGR 6DH9 6DHA 6E5A 6ENQ 6F2L 6FZF 6FZG 6FZJ 6FZP 6FZY 6ICJ 6IJR 6IJS 6ILQ 6IZM 6IZN 6JEY 6JF0 6JQ7 6K0T 6KTM 6KTN 6L89 6L8B 6MCZ 6MD0 6MD1 6MD2 6MD4 6MS7 6O67 6O68 6ONI 6ONJ 6PDZ 6QJ5 6T6B 6T9C 6TSG 6Y3U 7AHJ
Enriched GO Terms of Interacting Partners?
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