PPP1R13B and RALBP1

Data Source:
BioGRID (two hybrid)

		PPP1R13B	RALBP1
Description		protein phosphatase 1 regulatory subunit 13B	ralA binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Cytosol Membrane
	Molecular Function	P53 Binding Protein Binding Transcription Factor Binding	GTPase Activator Activity Protein Binding Transmembrane Transporter Activity Small GTPase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator	Endocytosis Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Doxorubicin Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	Rho GTPase cycle
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 26426971) General risk tolerance (MTAG) ( 30643258) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglycerides ( 30275531)	LDL cholesterol ( 30275531)
Interacting Genes		71 interacting genes: ACSF3 APC ARHGAP45 BFSP2 BRCA1 C2orf42 CAPN7 CBY2 CCDC102B CCDC184 CCHCR1 CDC5L CEP57 CEP63 CGN CKS1B DEUP1 DGCR6L DIRAS1 DTNB FAM184A FAM90A1 GAS2L2 GINS4 GOLGA1 HMG20B HNRNPUL1 KHDRBS1 KHDRBS3 KIF9 KIFC3 KRT20 KRT4 LMNB1 LMNB2 LMO1 LMO3 LNX1 MATN4 MCRS1 MIPOL1 MIS18A MLH1 NAP1L2 NDC80 NHSL2 PLEKHA5 PPFIA3 PPP1CA PPP1R18 PRKAB2 PRPH PRR35 RALBP1 RASAL3 RASSF8 SALL1 SOGA1 TCL1A TEKT4 TEX12 TEX9 TNIK TP63 TP73 TRAF1 TSG101 TSGA10 TXLNA ZGPAT ZZZ3	44 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CBY1 CCDC13 CCDC136 CCDC88B CCHCR1 CCNB1 CEP57 CREBZF FADD GAS8 GSE1 HOOK2 HSF1 IKBKG KANK2 LDOC1 MSANTD4 PCM1 PLCG2 PPP1R13B PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SAPCD2 SMARCE1 SYCE1 SYNJ2BP TBRG1 TCP10L TFPT TNIP1 TP53BP2 TRAF2 TSFM ZBTB38 ZNF707
Entrez ID		23368	10928
HPRD ID		07345	09013
Ensembl ID		ENSG00000088808	ENSG00000017797
Uniprot IDs		Q96KQ4	Q15311
PDB IDs		6HL5	2KWH 2KWI 2MBG
Enriched GO Terms of Interacting Partners?
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