ACSL6 and GATM

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ACSL6	GATM
Description		acyl-CoA synthetase long chain family member 6	glycine amidinotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Extracellular Exosome
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Protein Binding Amidinotransferase Activity Glycine Amidinotransferase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Lipid Biosynthetic Process Long-chain Fatty-acyl-CoA Biosynthetic Process	Creatine Metabolic Process Creatine Biosynthetic Process Multicellular Organism Development Learning Or Memory Muscle Atrophy Positive Regulation Of Cold-induced Thermogenesis
Pathways		Synthesis of very long-chain fatty acyl-CoAs	Creatine metabolism
Drugs			Ornithine Glycine Delta-Amino Valeric Acid gamma-Aminobutyric acid Norvaline Alpha-Aminobutyric Acid
Diseases			Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31152163 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Homoarginine levels ( 24047826) Metabolite levels (small molecules and protein measures) ( 27005778) Phosphatidylcholine-ether levels ( 31551469) Renal function and chronic kidney disease ( 19430482) Serum metabolite levels ( 24625756) Urinary albumin-to-creatinine ratio ( 31511532) Urinary potassium to creatinine ratio ( 30910378)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	1 interacting genes: CYP2E1
Entrez ID		23305	2628
HPRD ID		09190	03838
Ensembl ID		ENSG00000164398	ENSG00000171766
Uniprot IDs		B2RB13 B4DFW3 Q9UKU0	A0A140VK19 P50440
PDB IDs			1JDW 1JDX 2JDW 2JDX 3JDW 4JDW 5JDW 6JDW 7JDW 8JDW 9JDW
Enriched GO Terms of Interacting Partners?
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