MGRN1 and TRIM74

		MGRN1	TRIM74
Description		mahogunin ring finger 1	tripartite motif containing 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Monoubiquitination Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway	Protein Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Milk allergy (maternal genetic effects) ( 29489655) Triglyceride levels ( 32154731)
Interacting Genes		13 interacting genes: AMFR TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W	11 interacting genes: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32
Entrez ID		23295	378108
HPRD ID		07397	15567
Ensembl ID		ENSG00000102858	ENSG00000155428
Uniprot IDs		O60291	Q86UV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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