FAM168A and CAMK2A

Data Source:
BioGRID (two hybrid)

		FAM168A	CAMK2A
Description		family with sequence similarity 168 member A	calcium/calmodulin dependent protein kinase II alpha
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Endocytic Vesicle Membrane Neuron Projection Dendritic Spine
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Base-excision Repair	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Angiotensin-activated Signaling Pathway Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Dendritic Spine Development Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways			CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 28240269) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Waist-hip ratio ( 28552196)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)
Interacting Genes		75 interacting genes: ALKBH4 ATXN1 ATXN1L BOLL C10orf55 C1orf94 CALCOCO2 CAMK2A DAB1 DAZAP2 DCUN1D1 DTX2 EPN2 EPN3 FAM168B FBXW5 HGS HIP1 HR KLHL42 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 MEIS2 NAF1 NFYC OTUB2 OTULIN PATZ1 PEF1 PITX1 PLEKHB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSORS1C1 R3HDM2 RBFOX1 RBPMS RBPMS2 RHOXF2 RNF216 RPS27A SECISBP2 SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TFAP2D TFG TIAL1 TNIP1 TNK1 TOLLIP UBA52 UBAC1 UBASH3B UBC UBE2V1 UBQLN2 UBXN6 UBXN7 VPS37C YOD1 YTHDF1	87 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CAMK2B CAMK2D CAMK2G CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 EGFR ETS1 FAM168A FAM168B GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SQSTM1 SRF SUOX SYNGAP1 TAB2 TANC1 TCAF1 TEX37 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		23201	815
HPRD ID		13792	06532
Ensembl ID		ENSG00000054965	ENSG00000070808
Uniprot IDs		Q92567	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P
Enriched GO Terms of Interacting Partners?
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