MPRIP and PPP1R12A

Data Source:
HPRD (two hybrid, in vivo)

		MPRIP	PPP1R12A
Description		myosin phosphatase Rho interacting protein	protein phosphatase 1 regulatory subunit 12A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Focal Adhesion Actin Cytoskeleton	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex
	Molecular Function	Protein Binding Cadherin Binding Actin Filament Binding	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Actin Filament Organization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Cellular Response To Drug Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Establishment Of Endothelial Barrier
Pathways		Signaling by BRAF and RAF fusions	Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Obesity-related traits ( 23251661)	Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		14 interacting genes: ATXN7 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C PTEN RACGAP1 RHOA YTHDC1 YWHAB YWHAG YWHAQ	14 interacting genes: ATXN10 CDKN3 DMPK IL16 ILF3 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG
Entrez ID		23164	4659
HPRD ID		17591	03606
Ensembl ID		ENSG00000133030	ENSG00000058272
Uniprot IDs		Q6WCQ1 Q8N236	B2RAH5 O14974
PDB IDs			2KJY 5HUZ
Enriched GO Terms of Interacting Partners?
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