FRMD4B and CYTH3

Data Source:
HPRD (in vivo)

		FRMD4B	CYTH3
Description		FERM domain containing 4B	cytohesin 3
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Space Cytoplasm Cytoskeleton Adherens Junction Bicellular Tight Junction	Golgi Membrane Ruffle Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function		Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Establishment Of Epithelial Cell Polarity	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Regulation Of Catalytic Activity Establishment Of Epithelial Cell Polarity
Pathways			Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Atrial fibrillation ( 30061737) Carotid intima media thickness x smoking interaction ( 32117412) Celiac disease ( 20190752 31591516) Fast beta electroencephalogram ( 28040410) Hepcidin/ferritin ratio ( 27846281) High myopia ( 32428537) PR interval ( 30046033 32439900) Renal underexcretion gout ( 32238385) Resting heart rate ( 27798624) Resting-state electroencephalogram vigilance ( 29703947) Sphingomyelin 24:0 levels ( 31560688) Trunk fat mass ( 28552196)	Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321)
Interacting Genes		1 interacting genes: CYTH3	12 interacting genes: ARFIP2 CALCOCO1 CCDC120 CNKSR1 CYTIP FRMD4B IFI35 INAVA IPCEF1 PIK3CA SYCE1 TAMALIN
Entrez ID		23150	9265
HPRD ID		19415	05469
Ensembl ID		ENSG00000114541	ENSG00000008256
Uniprot IDs		B3KNA2 E9PGA7 Q6PEW6 Q9Y2L6	O43739
PDB IDs			4KAX 6U3E 6U3G
Enriched GO Terms of Interacting Partners?
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