SARM1 and NLRX1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SARM1	NLRX1
Description		sterile alpha and TIR motif containing 1	NLR family member X1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Microtubule Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction
	Molecular Function	NAD+ Nucleosidase Activity Protein Binding Signaling Adaptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Protein Binding ATP Binding
	Biological Process	Signal Transduction Nervous System Development Response To Glucose NAD Catabolic Process Cell Differentiation Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Response To Axon Injury Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death Positive Regulation Of Neuron Death	Viral Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Blood protein levels ( 29875488 28240269) Osteoprotegerin levels ( 25080503)	Mean reticulocyte volume ( 32888494)
Interacting Genes		6 interacting genes: CCDC47 IRAK2 MYD88 NLRX1 STT3A TICAM2	1 interacting genes: SARM1
Entrez ID		23098	79671
HPRD ID		09664	17640
Ensembl ID		ENSG00000004139	ENSG00000160703
Uniprot IDs		Q05B42 Q0D2N8 Q6SZW1	Q86UT6
PDB IDs		6O0Q 6O0R 6O0S 6O0T 6O0U 6O0V 6O1B 6QWV 6WPK 7CM5 7CM6 7CM7	3UN9
Enriched GO Terms of Interacting Partners?
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