KDM4C and H3C14

Data Source:
BioGRID (enzymatic study)

		KDM4C	H3C14
Description		lysine demethylase 4C	H3 clustered histone 14
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	Chromatin Binding Zinc Ion Binding Enzyme Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Androgen Receptor Binding Histone Demethylase Activity (H3-K36 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Histone H3-K9 Demethylation Positive Regulation Of Neuron Differentiation Histone H3-K36 Demethylation	RDNA Heterochromatin Assembly Chromatin Organization Nucleosome Assembly Blood Coagulation Interleukin-7-mediated Signaling Pathway Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing By MiRNA
Pathways		HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alanine transaminase levels ( 29403010) Artificially sweetened beverage consumption ( 31046077) Body mass index ( 25673413) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) HIV-1 susceptibility ( 25786224) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Radiation response ( 20923822) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia ( 30285260) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 26606652)
Interacting Genes		2 interacting genes: H3C1 H3C14	60 interacting genes: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFL2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 NAP1L4 NASP NCOA6 NRDC NSD2 PHF21A PIM1 PKN1 PRMT6 PTMA PWWP3A RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1
Entrez ID		23081	126961
HPRD ID		12016	11822
Ensembl ID		ENSG00000107077	ENSG00000203811
Uniprot IDs		B0QZ60 Q9H3R0	Q71DI3
PDB IDs		2XDP 2XML 4XDO 4XDP 5FJH 5FJK 5KR7	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93 4MZF 4MZG 4MZH 4OUC 5B0Y 5B0Z 5B40 5BO0 5CIU 5VAC 6ACE 6FML 6T79 6T7A 6T7B 6T7C 6T7D 6X59 6X5A 6XJD 6Y5D 6Y5E 7BQZ 7BU9 7JO9 7JOA
Enriched GO Terms of Interacting Partners?
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