FOXO1 and NCOA1

Data Source:
BioGRID (pull down)

		FOXO1	NCOA1
Description		forkhead box O1	nuclear receptor coactivator 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Neuron Projection
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Aryl Hydrocarbon Receptor Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Progesterone Receptor Binding Nuclear Hormone Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	Temperature Homeostasis Cellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Insulin Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Enamel Mineralization Cellular Response To Hydrogen Peroxide Cellular Response To Cold Response To Fatty Acid Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Energy Homeostasis Response To Fluoride Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Thyroid Hormone Mediated Signaling Pathway Lactation Male Gonad Development Bile Acid And Bile Salt Transport Regulation Of Lipid Metabolic Process Cerebellum Development Hippocampus Development Hypothalamus Development Cerebral Cortex Development Response To Estradiol Response To Retinoic Acid Response To Progesterone Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Histone H4 Acetylation Estrous Cycle Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior Labyrinthine Layer Morphogenesis Cellular Response To Thyroglobulin Triiodothyronine Regulation Of Cellular Response To Drug
Pathways		AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs			Genistein Corticosterone Prinaberel ERB-196 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL TO-901317 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE GW-590735 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 3,20-Pregnanedione Indeglitazar (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myristic acid 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Aleglitazar
Diseases		Alveolar rhabdomyosarcoma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 32528159 20485516 31798171 29760442 20719862) Corneal hysteresis ( 31246245 30894546) Corneal resistance factor ( 31246245 30894546) Corneal structure ( 23291589) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396 31649266) Weight ( 28552196)	Asthma ( 29273806) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chromium levels ( 26025379) Cognitive function ( 28093568) Diffuse large B cell lymphoma ( 25261932) Hand grip strength ( 29691431) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		38 interacting genes: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DANCR DYRK1A ESR1 FHL2 FOXG1 G6PC1 GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 UBE2D2 YWHAG YWHAZ	81 interacting genes: AHR ANKRD11 AR ARID1A ARNT BCL3 CARM1 CCND1 CIITA COPS5 CREBBP CXADR DDX17 DDX5 EP300 ESR1 ESR2 ESRRA ESRRG FOS FOXA2 FOXO1 GTF2B HIF1A HNF1A HNF4A HNF4G JUN KANK2 KAT2B MAPK1 NCOR1 NFKB1 NKX2-1 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR5A1 NR5A2 NR6A1 PAGR1 PGR PPARA PPARD PPARG PPARGC1A PRMT1 PRMT2 PSMB9 RARA RARB RARG RORA RORB RXRA RXRB SMARCC1 SMARCE1 SNW1 SRF STAT3 STAT6 SUMO1 TBP TEAD1 TEAD2 THRA THRB TP53 TRIM27 TRIP4 VDR YWHAH YWHAQ
Entrez ID		2308	8648
HPRD ID		00645	04070
Ensembl ID		ENSG00000150907	ENSG00000084676
Uniprot IDs		Q12778	Q15788
PDB IDs		3CO6 3CO7 3COA 4LG0 5DUI 6QVW 6QZR 6QZS	1FM6 1FM9 1K4W 1K74 1K7L 1KV6 1N4H 1NQ7 1NRL 1P8D 1PZL 1RDT 1TFC 1U3R 1U3S 1X76 1X78 1X7B 1X7J 1XIU 1XV9 1XVP 1YY4 1YYE 1ZAF 2A3I 2C52 2FVJ 2GTK 2HBH 2HC4 2HCD 2HFP 2NPA 2NV7 2P54 2PRG 3BEJ 3BQD 3CTB 3CWD 3DCT 3DCU 3DR1 3ET1 3ET3 3FEI 3FEJ 3FUR 3FXV 3G8I 3G9E 3GYT 3GYU 3H0A 3HC5 3HC6 3HVL 3IPQ 3IPS 3IPU 3KMR 3LMP 3OKH 3OKI 3OLF 3OLL 3OLS 3OMK 3OMM 3OMO 3OMP 3OMQ 3OOF 3OOK 3P88 3P89 3QT0 3RUT 3RUU 3RVF 3S9S 3T03 3UU7 3UUA 3UUD 3V9Y 3VN2 4DK7 4DK8 4DM6 4DM8 4DQM 4F9M 4FGY 4G1D 4G1Y 4G1Z 4G20 4G21 4G2H 4HEE 4J5X 4JYG 4JYH 4JYI 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGC 4MGD 4RUJ 4RUP 4TUZ 4TV1 4UDA 4UDB 4Y29 5A86 5AVI 5AVL 5AZT 5DSH 5DV3 5DV6 5DV8 5DVC 5DWL 5E7V 5GTN 5GTO 5GTP 5HJS 5JI0 5JMM 5L7E 5L7G 5L7H 5MWP 5MWY 5MX7 5NKY 5NMA 5NMB 5NWM 5OW7 5OW9 5OWD 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5X0R 5X8U 5X8W 5Y44 5YCN 5YCP 5YP6 6A5W 6A5X 6A5Y 6A5Z 6A60 6BNS 6E3G 6FO7 6FO8 6FO9 6FOB 6FOD 6GEV 6GG8 6HTY 6ICJ 6IJR 6IJS 6ILQ 6ITM 6JNR 6JQ7 6KTM 6KTN 6L96 6NX1 6P9F 6SSQ 6T2M 6U25 6W9H 6W9I 6XP9
Enriched GO Terms of Interacting Partners?
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