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FOXO1 and HOXA5
Data Source:
HPRD
(in vivo)
FOXO1
HOXA5
Description
forkhead box O1
homeobox A5
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Chromatin
Nucleus
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
Protein Phosphatase 2A Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Temperature Homeostasis
Cellular Glucose Homeostasis
Regulation Of Transcription By RNA Polymerase II
Protein Acetylation
Autophagy
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Insulin Receptor Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Autophagy
Cytokine-mediated Signaling Pathway
Endocrine Pancreas Development
Cellular Response To Insulin Stimulus
Negative Regulation Of Stress-activated MAPK Cascade
Cellular Response To Oxidative Stress
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Enamel Mineralization
Cellular Response To Hydrogen Peroxide
Cellular Response To Cold
Response To Fatty Acid
Cellular Response To Hyperoxia
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Energy Homeostasis
Response To Fluoride
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Respiratory System Process
Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Cell Migration
Negative Regulation Of Angiogenesis
Thyroid Gland Development
Regulation Of Mammary Gland Epithelial Cell Proliferation
Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Embryonic Skeletal System Morphogenesis
Bronchiole Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Lung Goblet Cell Differentiation
Lung-associated Mesenchyme Development
Trachea Cartilage Morphogenesis
Intestinal Epithelial Cell Maturation
Mesenchymal-epithelial Cell Signaling
Mammary Gland Epithelial Cell Differentiation
Mammary Gland Alveolus Development
Cell-cell Signaling Involved In Mammary Gland Development
Pathways
AKT phosphorylates targets in the nucleus
Regulation of gene expression in beta cells
AKT-mediated inactivation of FOXO1A
Constitutive Signaling by AKT1 E17K in Cancer
MAPK6/MAPK4 signaling
Interleukin-4 and Interleukin-13 signaling
Regulation of localization of FOXO transcription factors
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
Alveolar rhabdomyosarcoma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Arterial stiffness (
31070453
)
Arterial stiffness index (
31235810
)
Central corneal thickness (
32528159
20485516
31798171
29760442
20719862
)
Corneal hysteresis (
31246245
30894546
)
Corneal resistance factor (
31246245
30894546
)
Corneal structure (
23291589
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Granulocyte percentage of myeloid white cells (
27863252
)
Heel bone mineral density (
30598549
)
High light scatter reticulocyte count (
32888494
)
Intraocular pressure (
29617998
29235454
)
Mean corpuscular hemoglobin (
29403010
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
31649266
)
Weight (
28552196
)
Chronic venous disease (
28374850
)
Interacting Genes
38 interacting genes:
AKT1
AR
CEBPB
CREBBP
CSNK1G1
CTNNB1
DACH1
DANCR
DYRK1A
ESR1
FHL2
FOXG1
G6PC1
GSK3B
HNF4A
HOXA10
HOXA5
LRPPRC
MDM2
MST1
NCOA1
PAK1
PARP1
PIK3R3
PITX1
PPARG
RARA
SET
SFN
SIRT1
SMAD3
SMAD4
SRC
THRB
TNS2
UBE2D2
YWHAG
YWHAZ
16 interacting genes:
CDX4
CTBP2
DDIT3
DNMT3L
DVL3
FOXA2
FOXO1
GTF2A1L
MEIS1
PBX1
PBX2
PICK1
PRMT6
SMAD1
TWIST1
ZNF408
Entrez ID
2308
3202
HPRD ID
00645
00840
Ensembl ID
ENSG00000150907
ENSG00000106004
Uniprot IDs
Q12778
P20719
PDB IDs
3CO6
3CO7
3COA
4LG0
5DUI
6QVW
6QZR
6QZS
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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