ZHX3 and NFYA

Data Source:
HPRD (two hybrid)

		ZHX3	NFYA
Description		zinc fingers and homeoboxes 3	nuclear transcription factor Y subunit alpha
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Non-response to bupropion and depression ( 27622933) Refractive error ( 32231278) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Youthful appearance (self-reported) ( 32339537)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2	48 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		23051	4800
HPRD ID		10320	01793
Ensembl ID		ENSG00000174306	ENSG00000001167
Uniprot IDs		Q9H4I2	A0A024RD22 P23511
PDB IDs		2DA5 2DN0	4AWL 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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