NFYA and ZHX2

Data Source:
HPRD (in vivo, two hybrid)

		NFYA	ZHX2
Description		nuclear transcription factor Y subunit alpha	zinc fingers and homeoboxes 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Retinal Bipolar Neuron Differentiation
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)	Carotid intima media thickness ( 30510157 21909108) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		48 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3	9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3
Entrez ID		4800	22882
HPRD ID		01793	16458
Ensembl ID		ENSG00000001167	ENSG00000178764
Uniprot IDs		A0A024RD22 P23511	Q9Y6X8
PDB IDs		4AWL 6QMP 6QMQ 6QMS	2DMP 3NAU
Enriched GO Terms of Interacting Partners?
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