PALLD and ACTN2

Data Source:
HPRD (in vivo)

		PALLD	ACTN2
Description		palladin, cytoskeletal associated protein	actinin alpha 2
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GO Annotations	Cellular Component	Stress Fiber Ruffle Podosome Nucleus Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium Axon Growth Cone Excitatory Synapse	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Actin Binding Protein Binding Muscle Alpha-actinin Binding Cell-cell Adhesion Mediator Activity	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Nuclear Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Cell Migration Actin Cytoskeleton Organization Dendrite Self-avoidance	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity
Pathways			Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS		Advanced glycation end-product levels ( 26915486) Bacteremia ( 27236921) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Pulse pressure ( 28135244 27841878 30578418) Response to iloperidone treatment (QT prolongation) ( 18521091) Systolic blood pressure ( 30578418) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		12 interacting genes: ACTN1 ACTN2 CDC42 EZR HOMER2 HOMER3 ITGB5 LIG4 PDLIM3 SORBS2 SRPK2 SUMO2	104 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 ODF3B PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2
Entrez ID		23022	88
HPRD ID		09731	00019
Ensembl ID		ENSG00000129116	ENSG00000077522
Uniprot IDs		B2RTX2 Q8WX93	F6THM6 P35609 Q59FD9
PDB IDs		2DM2 2DM3	1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT
Enriched GO Terms of Interacting Partners?
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