ACTN2 and MYPN

Data Source:
HPRD (two hybrid)

		ACTN2	MYPN
Description		actinin alpha 2	myopalladin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Plasma Membrane Z Disc Axon I Band
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Nuclear Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Muscle Alpha-actinin Binding Cell-cell Adhesion Mediator Activity
	Biological Process	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Sarcomere Organization Dendrite Self-avoidance
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737) Chronic kidney disease ( 31152163) Coffee consumption ( 31046077) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 29403010) Height ( 25282103) Lung function (FVC) ( 28166213 30804560) Optic nerve measurement (disc area) ( 20395239) Peak expiratory flow ( 30804560) Psoriasis ( 25854761)
Interacting Genes		104 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKTIP ANG ANGPTL7 ASH2L ATP5MC1 ATXN2 ATXN7 BAD BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CCDC187 CD27 CLEC4D CNNM3 COIL CRABP2 CRADD DISC1 DLG1 DLG4 DUX1 DYNLT2B EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 HTR1B ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MAST2 MED14 MICALL2 MOS MRPL10 MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NKAPD1 NOS3 NR1I2 NRIP1 NTAQ1 ODF3B PALLD PDLIM1 PDLIM3 PKD2 PPP1CB PPP1R9B PSMA1 QARS1 RACK1 RAVER1 RPL35 RPP14 RTP5 SAXO1 SELE SNAI1 SNAPIN SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 SYNPO2L TNN TOLLIP TTN TULP3 USP2 UTRN ZC2HC1C ZNF446 ZNRD2	8 interacting genes: ACTN2 ACTN3 ANKRD1 ANKRD23 NEB NEBL PDLIM3 TTN
Entrez ID		88	84665
HPRD ID		00019	10536
Ensembl ID		ENSG00000077522	ENSG00000138347
Uniprot IDs		F6THM6 P35609 Q59FD9	A0A087WX60 Q86TC9
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B 6SWT
Enriched GO Terms of Interacting Partners?
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