Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ACTN2 and MYPN
Data Source:
HPRD
(two hybrid)
ACTN2
MYPN
Description
actinin alpha 2
myopalladin
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Exosome
Postsynaptic Density Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Nucleus
Plasma Membrane
Z Disc
Axon
I Band
Molecular Function
Integrin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Protein Domain Specific Binding
LIM Domain Binding
Nuclear Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Actin Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Muscle Alpha-actinin Binding
Cell-cell Adhesion Mediator Activity
Biological Process
MAPK Cascade
Platelet Degranulation
Cell Adhesion
Microspike Assembly
Muscle Filament Sliding
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Sarcomere Organization
Positive Regulation Of Transcription, DNA-templated
Focal Adhesion Assembly
Actin Filament Uncapping
Cardiac Muscle Cell Development
Protein Localization To Plasma Membrane
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Protein Localization To Cell Surface
Regulation Of NMDA Receptor Activity
Positive Regulation Of Endocytic Recycling
Positive Regulation Of Cation Channel Activity
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Axon Guidance
Sarcomere Organization
Dendrite Self-avoidance
Pathways
Platelet degranulation
Nephrin family interactions
Striated Muscle Contraction
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Periodontitis (CDC/AAP) (
24024966
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
30061737
)
Chronic kidney disease (
31152163
)
Coffee consumption (
31046077
)
Creatine kinase levels (
29403010
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
FEV1 (
30804560
)
Glomerular filtration rate (
29403010
)
Height (
25282103
)
Lung function (FVC) (
28166213
30804560
)
Optic nerve measurement (disc area) (
20395239
)
Peak expiratory flow (
30804560
)
Psoriasis (
25854761
)
Interacting Genes
104 interacting genes:
ACTN1
ACTN3
ADAM12
ADORA2A
AKTIP
ANG
ANGPTL7
ASH2L
ATP5MC1
ATXN2
ATXN7
BAD
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
CCDC187
CD27
CLEC4D
CNNM3
COIL
CRABP2
CRADD
DISC1
DLG1
DLG4
DUX1
DYNLT2B
EPS8L1
ERBIN
FAM50B
FBXL22
GATA3
GOLGA7
GRIN1
GRIN2B
GSTT1
H4C9
HSPB1
HTR1B
ITGB3BP
KAT2B
KATNAL2
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MAST2
MED14
MICALL2
MOS
MRPL10
MYBPC2
MYOT
MYOZ1
MYOZ2
MYOZ3
MYPN
NCAPH2
NCOA2
NCOR1
NKAPD1
NOS3
NR1I2
NRIP1
NTAQ1
ODF3B
PALLD
PDLIM1
PDLIM3
PKD2
PPP1CB
PPP1R9B
PSMA1
QARS1
RACK1
RAVER1
RPL35
RPP14
RTP5
SAXO1
SELE
SNAI1
SNAPIN
SNW1
SP100
SPA17
SRP9
SSX2IP
ST7
SYNPO2
SYNPO2L
TNN
TOLLIP
TTN
TULP3
USP2
UTRN
ZC2HC1C
ZNF446
ZNRD2
8 interacting genes:
ACTN2
ACTN3
ANKRD1
ANKRD23
NEB
NEBL
PDLIM3
TTN
Entrez ID
88
84665
HPRD ID
00019
10536
Ensembl ID
ENSG00000077522
ENSG00000138347
Uniprot IDs
F6THM6
P35609
Q59FD9
A0A087WX60
Q86TC9
PDB IDs
1H8B
1HCI
1QUU
4D1E
5A36
5A37
5A38
5A4B
6SWT
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?