MAPRE1 and CYLD

Data Source:
BioGRID (two hybrid)

		MAPRE1	CYLD
Description		microtubule associated protein RP/EB family member 1	CYLD lysine 63 deubiquitinase
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GO Annotations	Cellular Component	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Spindle Midzone Mitotic Spindle Astral Microtubule End	Centrosome Spindle Cytosol Cytoplasmic Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ciliary Basal Body Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding Protein Kinase Binding Lys63-specific Deubiquitinase Activity Proline-rich Region Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Bundle Formation Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Positive Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end Non-motile Cilium Assembly	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of JNK Cascade Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Protein Linear Deubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases			Familial cylindromatosis Multiple familial trichoepithelioma Brooke-Spiegler syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 28067908 22412388) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 25642632 22019778) Lumbar spine bone mineral density ( 29499414 22504420)
Interacting Genes		55 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GAS2L2 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MAPRE2 MAPRE3 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB ZNF653	23 interacting genes: AKT1 AURKB DDX58 DLG4 HDAC6 IKBKE IKBKG ITCH MAP3K7 MAPRE1 PLK4 PTPA TBK1 TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2D2 UBE2S
Entrez ID		22919	1540
HPRD ID		04379	05427
Ensembl ID		ENSG00000101367	ENSG00000083799
Uniprot IDs		Q15691	A0A024R6T1 Q9NQC7
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH	1IXD 1WHL 1WHM 2VHF
Enriched GO Terms of Interacting Partners?
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