MAPRE1 and PIK3R4

Data Source:
HPRD (in vitro)

		MAPRE1	PIK3R4
Description		microtubule associated protein RP/EB family member 1	phosphoinositide-3-kinase regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Ciliary Basal Body Spindle Midzone Mitotic Spindle Astral Microtubule End	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Bundle Formation Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Positive Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end Non-motile Cilium Assembly	Protein Phosphorylation Protein Targeting To Vacuole Phosphatidylinositol Biosynthetic Process Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Toll-like Receptor 9 Signaling Pathway Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean platelet volume ( 32888494) Oily fish consumption ( 32066663) Polycystic ovary syndrome ( 30566500) Pork consumption ( 32066663) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Abdominal aortic calcification levels ( 31659325) Refractive error ( 32231278)
Interacting Genes		55 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 C20orf202 CASK CCSER1 CDC42 CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GAS2L2 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL12 KLHL21 KNSTRN LMO2 LRP1 MACF1 MAPRE2 MAPRE3 MARCHF7 MEOX2 NAV1 NUPR1 PAX6 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SPDYE2B SRC SRPK2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB ZNF653	6 interacting genes: FNDC3B MAPRE1 NRBF2 PIK3C3 RACK1 YWHAB
Entrez ID		22919	30849
HPRD ID		04379	04010
Ensembl ID		ENSG00000101367	ENSG00000196455
Uniprot IDs		Q15691	Q99570
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ 6PF2 6PFP 6YF5 6YSH
Enriched GO Terms of Interacting Partners?
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