NTMT1 and DDB2

Data Source:
BioGRID (enzymatic study)

		NTMT1	DDB2
Description		N-terminal Xaa-Pro-Lys N-methyltransferase 1	damage specific DNA binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Histone Methyltransferase Activity N-terminal Protein N-methyltransferase Activity	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	N-terminal Protein Amino Acid Methylation Spindle Organization Chromosome Segregation Histone Methylation N-terminal Peptidyl-alanine Methylation N-terminal Peptidyl-alanine Trimethylation N-terminal Peptidyl-glycine Methylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-proline Methylation N-terminal Peptidyl-serine Methylation N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation	Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV Protein Deubiquitination Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Post-translational Protein Modification Protein Autoubiquitination Global Genome Nucleotide-excision Repair UV-damage Excision Repair
Pathways			Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Acne (severe) ( 24399259) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling lonely ( 29500382) Feeling miserable ( 29500382) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: APP DDB2 DIS3 GLYR1 HNRNPD IKBKG RCC1	19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 PAQR3 RAD51 TOP1 USP24 USP40 XPA XPC
Entrez ID		28989	1643
HPRD ID		10628	02886
Ensembl ID		ENSG00000148335	ENSG00000134574
Uniprot IDs		A0A024R8E4 Q9BV86 S4R338	Q92466
PDB IDs		2EX4 5CVD 5CVE 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 6DTN 6KDQ 6PVA 6PVB 6WH8 6WJ7	3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92
Enriched GO Terms of Interacting Partners?
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