ZHX2 and RAB7A

Data Source:
BioGRID (affinity chromatography technology)

		ZHX2	RAB7A
Description		zinc fingers and homeoboxes 2	RAB7A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Retinal Bipolar Neuron Differentiation	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways			MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Carotid intima media thickness ( 30510157 21909108) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3	27 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 SNX3 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41
Entrez ID		22882	7879
HPRD ID		16458	03805
Ensembl ID		ENSG00000178764	ENSG00000075785
Uniprot IDs		Q9Y6X8	A0A158RFU6 P51149
PDB IDs		2DMP 3NAU	1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?