ZHX2 and ZHX3

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, in vitro, two hybrid)

		ZHX2	ZHX3
Description		zinc fingers and homeoboxes 2	zinc fingers and homeoboxes 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Retinal Bipolar Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Carotid intima media thickness ( 30510157 21909108) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Non-response to bupropion and depression ( 27622933) Refractive error ( 32231278) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3	6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2
Entrez ID		22882	23051
HPRD ID		16458	10320
Ensembl ID		ENSG00000178764	ENSG00000174306
Uniprot IDs		Q9Y6X8	Q9H4I2
PDB IDs		2DMP 3NAU	2DA5 2DN0
Enriched GO Terms of Interacting Partners?
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