DZIP1 and PPP2R5A

Data Source:
BioGRID (two hybrid)

		DZIP1	PPP2R5A
Description		DAZ interacting zinc finger protein 1	protein phosphatase 2 regulatory subunit B'alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Centriolar Satellite Ciliary Basal Body Ciliary Transition Fiber	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band
	Molecular Function	Protein Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Smoothened Signaling Pathway Multicellular Organism Development Germ Cell Development Spermatogenesis Regulation Of Protein Binding Establishment Of Protein Localization Positive Regulation Of Cilium Assembly Cytoplasmic Sequestering Of Protein Cilium Assembly Protein Localization To Cilium	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Hedgehog 'on' state	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Glomerular filtration rate (cystatin C) ( 26831199) Response to statins (LDL cholesterol change) ( 25350695)	Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379)
Interacting Genes		9 interacting genes: DAZ1 DAZ4 LUC7L2 MOS OPTN PPP1R18 PPP2R5A PRPF40A TNS2	27 interacting genes: APC AXIN2 BCL2 BEST1 C1orf21 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1
Entrez ID		22873	5525
HPRD ID		16363	03384
Ensembl ID		ENSG00000134874	ENSG00000066027
Uniprot IDs		B3KSP1 Q86YF9	Q15172
PDB IDs			6NTS
Enriched GO Terms of Interacting Partners?
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