PPP2R5A and GNL3

Data Source:
HPRD (in vivo, two hybrid)

		PPP2R5A	GNL3
Description		protein phosphatase 2 regulatory subunit B'alpha	G protein nucleolar 3
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Centrosome Cytosol Membrane Z Disc M Band	Extracellular Space Nucleus Chromosome Nucleolus Membrane Nuclear Body Midbody
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity	RNA Binding Protein Binding GTP Binding MRNA 5'-UTR Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Protein Localization To Plasma Membrane	Cell Population Proliferation Stem Cell Division Stem Cell Population Maintenance Positive Regulation Of Telomere Maintenance Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379)	Adiponectin levels ( 22479202) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intelligence (MTAG) ( 29326435) Osteoarthritis ( 22763110) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		27 interacting genes: APC AXIN2 BCL2 BEST1 C1orf21 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1	9 interacting genes: ASCC2 CEP19 DYSF MDM2 NPM1 PPP2R5A PTEN STAT3 TP53
Entrez ID		5525	26354
HPRD ID		03384	06419
Ensembl ID		ENSG00000066027	ENSG00000163938
Uniprot IDs		Q15172	Q9BVP2
PDB IDs		6NTS
Enriched GO Terms of Interacting Partners?
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