PHLDA1 and RPL14

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		PHLDA1	RPL14
Description		pleckstrin homology like domain family A member 1	ribosomal protein L14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Cytoplasmic Vesicle	Cytosol Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol Phosphate Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Positive Regulation Of Apoptotic Process FasL Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Ribosomal Large Subunit Biogenesis
Pathways		Interaction between PHLDA1 and AURKA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 30061737 29892015) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Neuroticism ( 29255261)
Interacting Genes		41 interacting genes: APP CDPF1 CYSRT1 EIF3D F2RL1 FBXO7 HSPA4 HSPA4L KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP5-1 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS13 MDFI NBPF19 NOTCH2NLA PABPC4 PLSCR1 RPL14 TRAF4 TRIM42 TSPAN4	7 interacting genes: FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6
Entrez ID		22822	9045
HPRD ID		05625	10617
Ensembl ID		ENSG00000139289	ENSG00000188846
Uniprot IDs		Q8WV24	P50914
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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