CASC3 and PHB

Data Source:
BioGRID (two hybrid)

		CASC3	PHB
Description		CASC3 exon junction complex subunit	prohibitin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Dendrite Nuclear Membrane Exon-exon Junction Complex Perinuclear Region Of Cytoplasm U2-type Catalytic Step 1 Spliceosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Mitochondrial Crista Extrinsic Component Of Mitochondrial Outer Membrane Mitochondrial Prohibitin Complex Extracellular Exosome Extrinsic Component Of Presynaptic Active Zone Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Regulation Of Translation Intracellular MRNA Localization MRNA 3'-end Processing	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Ovarian Follicle Atresia Osteoblast Differentiation Immunoglobulin Production Regulation Of Transcription, DNA-templated Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Signal Transduction Activation Of Phospholipase C Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation CD40 Signaling Pathway Negative Regulation Of Cell Growth Animal Organ Regeneration Interleukin-17 Production Response To Immobilization Stress RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Peptide Hormone Modulation By Host Of Viral RNA Genome Replication Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Viral Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs			Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Asthma ( 31619474) Household income ( 31844048)	Asthma ( 31959851 30929738 32296059 29273806) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Cancer ( 29299148) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 19430483 27841878) Lower body strength ( 27325353) Metabolite levels ( 23823483) Prostate cancer ( 23535732) Refractive error ( 32231278) Restricted and repetitive behaviours in autism spectrum disorder ( 28533516) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		16 interacting genes: AKT1 APC CASP8 CDK6 CDKN2A EIF4A3 ESR2 FGFR4 GRB2 KRTAP6-2 MIR128-1 NBN PHB PTPN1 PTPRJ STAU1	25 interacting genes: ANXA2 BCAS3 CASC3 CCL5 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1
Entrez ID		22794	5245
HPRD ID		16225	01454
Ensembl ID		ENSG00000108349	ENSG00000167085
Uniprot IDs		O15234	A8K401 P35232 Q53FV0
PDB IDs		2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 5XJC 5YZG 6ICZ	1LU7
Enriched GO Terms of Interacting Partners?
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