DOK1 and ITGB7

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		DOK1	ITGB7
Description		docking protein 1	integrin subunit beta 7
Image
GO Annotations	Cellular Component	Nucleus Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Viral Entry Into Host Cell Regulation Of Immune Response Leukocyte Tethering Or Rolling T Cell Migration
Pathways		PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs			R1295 Vedolizumab
Diseases
GWAS		Height ( 31562340)	Obesity-related traits ( 23251661)
Interacting Genes		41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1	15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1
Entrez ID		1796	3695
HPRD ID		04228	00948
Ensembl ID		ENSG00000115325	ENSG00000139626
Uniprot IDs		B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704	P26010
PDB IDs		2V76	2BRQ 3V4P 3V4V
Enriched GO Terms of Interacting Partners?
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