PTX3 and FGF5

Data Source:
BioGRID (pull down)

		PTX3	FGF5
Description		pentraxin 3	fibroblast growth factor 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding	Fibroblast Growth Factor Receptor Binding Growth Factor Activity
	Biological Process	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Glial Cell Differentiation Positive Regulation Of Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 24954895 21909110) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 31152163) Coronary artery disease ( 32469254 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Diastolic blood pressure ( 26390057 27736895 28135244 19430483 27841878 21909115 29403010 28739976 27618447 27618452 25249183 30487518 28871152) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Gout (combined type) ( 32238385) Hemoglobin levels ( 32327693) Hypertension ( 25249183 30487518) LDL cholesterol levels ( 32203549) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure ( 26390057 29403010 30487518 28871152) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monobrow ( 27182965) Potassium levels ( 29403010) PR interval ( 32439900) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 26390057 27736895 28135244 27841878 21909115 29403010 28739976 27618452 25249183 30487518 28871152 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A	5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3
Entrez ID		5806	2250
HPRD ID		03928	01307
Ensembl ID		ENSG00000163661	ENSG00000138675
Uniprot IDs		P26022	P12034 Q8NBG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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