ABCD2 and PEX19

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		ABCD2	PEX19
Description		ATP binding cassette subfamily D member 2	peroxisomal biogenesis factor 19
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane	Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Brush Border Membrane Protein-containing Complex
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity	Protein Binding Peroxisome Membrane Targeting Sequence Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-terminus Binding ATPase Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Positive Regulation Of Fatty Acid Beta-oxidation Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Transmembrane Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Transmembrane Transport Chaperone-mediated Protein Folding Chaperone-mediated Protein Transport Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Interacting Genes		3 interacting genes: ABCD1 ABCD3 PEX19	38 interacting genes: ABCD1 ABCD2 ABCD3 BCL2L11 CDC25A CDKN2A EIF1B F11R FKBP7 GSKIP IFNB1 IL23A IRF3 KIFAP3 MFSD5 NAT8L OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PSORS1C2 PXMP4 SLC25A17 SLC34A1 SMAD2 SRPK1 STK3 SUOX TMEM54 TXN2
Entrez ID		225	5824
HPRD ID		03051	02610
Ensembl ID		ENSG00000173208	ENSG00000162735
Uniprot IDs		Q9UBJ2	A0A0S2Z497 P40855
PDB IDs			2W85 2WL8 3AJB 3MK4 5LNF
Enriched GO Terms of Interacting Partners?
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