ABCD2 and ABCD1

Data Source:
HPRD (two hybrid, in vivo)

		ABCD2	ABCD1
Description		ATP binding cassette subfamily D member 2	ATP binding cassette subfamily D member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane	Cytoplasm Lysosomal Membrane Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity	Long-chain Fatty Acid Transporter Activity Protein Binding ATP Binding ABC-type Fatty-acyl-CoA Transporter Activity ATPase Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Positive Regulation Of Fatty Acid Beta-oxidation Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Transmembrane Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Regulation Of Oxidative Phosphorylation Fatty Acid Beta-oxidation Peroxisome Organization Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import
Drugs
Diseases			Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS
Interacting Genes		3 interacting genes: ABCD1 ABCD3 PEX19	5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2
Entrez ID		225	215
HPRD ID		03051	02300
Ensembl ID		ENSG00000173208	ENSG00000101986
Uniprot IDs		Q9UBJ2	P33897
PDB IDs
Enriched GO Terms of Interacting Partners?
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