FBLN1 and PLSCR1

Data Source:
BioGRID (two hybrid)

		FBLN1	PLSCR1
Description		fibulin 1	phospholipid scramblase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		62 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TDGF1 TRIM42 UNKL VCAN YWHAQ	129 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764
Entrez ID		2192	5359
HPRD ID		00629	08855
Ensembl ID		ENSG00000077942	ENSG00000188313
Uniprot IDs		P23142 Q8NBH6	O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?
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