FDXR and FDX1

Data Source:
HPRD (in vitro)

		FDXR	FDX1
Description		ferredoxin reductase	ferredoxin 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix
	Molecular Function	Ferredoxin-NADP+ Reductase Activity NADPH-adrenodoxin Reductase Activity Oxidoreductase Activity	Iron Ion Binding Electron Transfer Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Ubiquinone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process	C21-steroid Hormone Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Electron Transport Chain Hormone Biosynthetic Process Small Molecule Metabolic Process Cellular Response To CAMP Cellular Response To Forskolin
Pathways		Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Flavin adenine dinucleotide Nicotinamide adenine dinucleotide phosphate	Mitotane
Diseases
GWAS			Cognitive function ( 24684796) Coronary artery disease ( 32469254)
Interacting Genes		4 interacting genes: FDX1 FHIT MTNR1A POU2F1	5 interacting genes: CYCS CYP11A1 CYP11B2 FDXR PRKAB2
Entrez ID		2232	2230
HPRD ID		00060	00059
Ensembl ID		ENSG00000161513	ENSG00000137714
Uniprot IDs		A0A0A0MSZ4 A0A0A0MT64 A0A0A0MTN9 A0A0A0MTR6 A0A0C4DFN8 A0A0C4DGN7 P22570	P10109
PDB IDs			3N9Y 3N9Z 3NA0 3NA1 3P1M
Enriched GO Terms of Interacting Partners?
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