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YES1 and SOCS3
Data Source:
BioGRID
(two hybrid, two hybrid)
YES1
SOCS3
Description
YES proto-oncogene 1, Src family tyrosine kinase
suppressor of cytokine signaling 3
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Extracellular Exosome
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Ion Channel Binding
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Protein Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Biological Process
Cellular Protein Modification Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
T Cell Costimulation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Innate Immune Response
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Negative Regulation Of Protein Kinase Activity
Receptor Signaling Pathway Via JAK-STAT
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Growth
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Negative Regulation Of Inflammatory Response
Regulation Of Interferon-gamma-mediated Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Trophoblast Giant Cell Differentiation
Interleukin-6-mediated Signaling Pathway
Cellular Response To Leukemia Inhibitory Factor
Pathways
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Dasatinib
Fostamatinib
Diseases
GWAS
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
30224653
29403010
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Interacting Genes
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GAS8
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
PXN
RASA1
RPL10
SH3GLB2
SKAP2
SLC9A3R1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
63 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
Entrez ID
7525
9021
HPRD ID
01285
05006
Ensembl ID
ENSG00000176105
ENSG00000184557
Uniprot IDs
P07947
O14543
Q6FI39
PDB IDs
2HDA
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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