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YES1 and CD36
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
YES1
CD36
Description
YES proto-oncogene 1, Src family tyrosine kinase
CD36 molecule
Image
GO Annotations
Cellular Component
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Extracellular Exosome
Extracellular Space
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Platelet Alpha Granule Membrane
Brush Border Membrane
Specific Granule Membrane
Receptor Complex
Membrane Raft
Phagocytic Vesicle
Cell Periphery
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Ion Channel Binding
Amyloid-beta Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Long-chain Fatty Acid Transporter Activity
Protein Binding
High-density Lipoprotein Particle Binding
Lipid Binding
Short-chain Fatty Acid Transmembrane Transporter Activity
Low-density Lipoprotein Particle Binding
Toll-like Receptor Binding
Protein-containing Complex Binding
Transforming Growth Factor Beta Binding
Thrombospondin Receptor Activity
Lipoteichoic Acid Immune Receptor Activity
Lipoprotein Particle Binding
Oxidised Low-density Lipoprotein Particle Receptor Activity
Oleate Transmembrane Transporter Activity
Biological Process
Cellular Protein Modification Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
T Cell Costimulation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Innate Immune Response
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell-matrix Adhesion
Toll-like Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Production Of Molecular Mediator Involved In Inflammatory Response
Platelet Degranulation
MyD88-dependent Toll-like Receptor Signaling Pathway
Lipid Metabolic Process
Fatty Acid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Cell Adhesion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Storage
Positive Regulation Of Cell Death
Long-chain Fatty Acid Transport
Long-chain Fatty Acid Import Across Plasma Membrane
Short-chain Fatty Acid Transport
Regulation Of Lipid Metabolic Process
Cytokine-mediated Signaling Pathway
Lipid Storage
CGMP-mediated Signaling
Positive Regulation Of Blood Coagulation
Intestinal Cholesterol Absorption
Cholesterol Transport
Receptor Internalization
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Lipid
Regulation Of Toll-like Receptor Signaling Pathway
Triglyceride Transport
Plasma Lipoprotein Particle Clearance
Low-density Lipoprotein Particle Clearance
Response To Stilbenoid
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Protein Import Into Nucleus
Lipoprotein Transport
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Apoptotic Cell Clearance
Neutrophil Degranulation
Long-chain Fatty Acid Import Into Cell
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-positive Bacterium
Intestinal Absorption
Sensory Perception Of Taste
Positive Regulation Of NF-kappaB Transcription Factor Activity
Low-density Lipoprotein Particle Mediated Signaling
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Cholesterol Import
Response To Fatty Acid
Response To Linoleic Acid
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hydroperoxide
Cellular Response To Diacyl Bacterial Lipopeptide
Energy Homeostasis
Regulation Of Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Oxidised Low-density Lipoprotein Particle Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Amyloid Fibril Formation
Lipid Transport Across Blood-brain Barrier
Regulation Of Removal Of Superoxide Radicals
Positive Regulation Of Blood Microparticle Formation
Pathways
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
PPARA activates gene expression
Scavenging by Class B Receptors
Scavenging by Class B Receptors
Transcriptional regulation of white adipocyte differentiation
Intracellular metabolism of fatty acids regulates insulin secretion
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Drugs
Dasatinib
Fostamatinib
Diseases
GWAS
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
30224653
29403010
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Aspartate aminotransferase levels (
29403010
)
Basophil count (
32888494
)
Blood protein levels (
30072576
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol (
23726366
30275531
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hemoglobin (
32888494
)
High density lipoprotein cholesterol levels (
29403010
)
Left ventricular mass (
19454037
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Night sleep phenotypes (
27126917
)
Platelet count (
29403010
32888494
22423221
27863252
)
Plateletcrit (
32888494
)
Red blood cell count (
32888494
27863252
)
Red cell distribution width (
32888494
28957414
)
Response to fenofibrate (
22890011
)
Interacting Genes
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GAS8
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
PXN
RASA1
RPL10
SH3GLB2
SKAP2
SLC9A3R1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
19 interacting genes:
APOB
APP
CD9
CHRD
COL1A1
COL1A2
FYN
HSD11B1
ITGA2B
ITGA6
ITGB1
ITGB3
LDLR
LYN
MATK
SRC
THBS1
VLDLR
YES1
Entrez ID
7525
948
HPRD ID
01285
01430
Ensembl ID
ENSG00000176105
ENSG00000135218
Uniprot IDs
P07947
A4D1B1
B7Z6C3
E9PLT1
P16671
PDB IDs
2HDA
5LGD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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