FCER2 and CR2

Data Source:
HPRD (in vitro)

		FCER2	CR2
Description		Fc fragment of IgE receptor II	complement C3d receptor 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding IgE Binding Carbohydrate Binding Metal Ion Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation Regulation Of Complement Activation B Cell Proliferation Viral Entry Into Host Cell
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Regulation of Complement cascade
Drugs		Lumiliximab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Post bronchodilator FEV1 ( 26634245)	Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		5 interacting genes: ATF7 CR2 FYN ITGAX ITGB2	10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		2208	1380
HPRD ID		01049	00399
Ensembl ID		ENSG00000104921	ENSG00000117322
Uniprot IDs		K3W4U1 P06734	P20023
PDB IDs		1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED
Enriched GO Terms of Interacting Partners?
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