FCER2 and ITGAX

Data Source:
HPRD (in vivo)

		FCER2	ITGAX
Description		Fc fragment of IgE receptor II	integrin subunit alpha X
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Integrin Binding Protein Binding IgE Binding Carbohydrate Binding Metal Ion Binding	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Neutrophil Degranulation Positive Regulation Of Angiogenesis Leukocyte Migration Positive Regulation Of Endothelial Tube Morphogenesis
Pathways		NOTCH2 intracellular domain regulates transcription Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Lumiliximab	Efalizumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Post bronchodilator FEV1 ( 26634245)	IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)
Interacting Genes		5 interacting genes: ATF7 CR2 FYN ITGAX ITGB2	5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3
Entrez ID		2208	3687
HPRD ID		01049	01051
Ensembl ID		ENSG00000104921	ENSG00000140678
Uniprot IDs		K3W4U1 P06734	H3BN02 P20702
PDB IDs		1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P 4J6Q 4KI1 5LGK	1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4
Enriched GO Terms of Interacting Partners?
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