CR2 and ANXA6

Data Source:
HPRD (in vitro)

		CR2	ANXA6
Description		complement C3d receptor 2	annexin A6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome	Cytoplasm Mitochondrion Lysosomal Membrane Focal Adhesion Membrane Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity	Phosphatidylserine Binding Calcium Channel Activity Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Ion Channel Activity Cholesterol Binding Chondroitin Sulfate Binding Identical Protein Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation Regulation Of Complement Activation B Cell Proliferation Viral Entry Into Host Cell	Neural Crest Cell Migration Plasma Membrane Repair Growth Plate Cartilage Chondrocyte Differentiation Regulation Of Muscle Contraction Ion Transmembrane Transport Negative Regulation Of Sequestering Of Calcium Ion Mitochondrial Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway
Pathways		Regulation of Complement cascade	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Psoriasis ( 25903422 25574825) Psoriatic arthritis ( 26626624)
Interacting Genes		10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53	16 interacting genes: A2M CDC73 CR2 ERBB2 IL16 LINC01554 LMNA MLH1 MTNR1B RASA1 RHOU S100A1 S100B SMURF1 SNCA TPD52
Entrez ID		1380	309
HPRD ID		00399	00231
Ensembl ID		ENSG00000117322	ENSG00000197043
Uniprot IDs		P20023	A0A0S2Z2Z6 P08133
PDB IDs		1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED	1M9I
Enriched GO Terms of Interacting Partners?
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