FBLN2 and VCAN

Data Source:
HPRD (in vitro)

		FBLN2	VCAN
Description		fibulin 2	versican
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Vesicle	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization	Skeletal System Development Osteoblast Differentiation Cell Adhesion Multicellular Organism Development Central Nervous System Development Cell Recognition Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs			Hyaluronic acid
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Appendicular lean mass ( 28724990) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness (mean) ( 31801372) Cortical surface area (MOSTest) ( 32665545) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Joint mobility (Beighton score) ( 27182965) Laryngeal squamous cell carcinoma ( 25194280) Lean body mass ( 28724990) Major depressive disorder ( 20516156) Optic disc size ( 31809533) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter hyperintensity volume ( 29752348) White matter integrity (fractional anisotropy) ( 29752348 32358547) White matter integrity (mean diffusivity) ( 29752348 32358547)
Interacting Genes		30 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 OTX1 PRELP VCAN ZNF408 ZNF414	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		2199	1462
HPRD ID		00630	00340
Ensembl ID		ENSG00000163520	ENSG00000038427
Uniprot IDs		P98095 Q86V58 Q9Y3V7	A0A024RAL1 A0A024RAP3 A0A024RAQ9 P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs
Enriched GO Terms of Interacting Partners?
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