FBLN2 and COL4A2

Data Source:
HPRD (in vivo)

		FBLN2	COL4A2
Description		fibulin 2	collagen type IV alpha 2 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Vesicle	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization	Angiogenesis Transcription, DNA-templated Aging Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Apolipoprotein B levels ( 32203549) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Retinal arteriolar tortuosity ( 31597446) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		30 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 OTX1 PRELP VCAN ZNF408 ZNF414	24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL
Entrez ID		2199	1284
HPRD ID		00630	00355
Ensembl ID		ENSG00000163520	ENSG00000134871
Uniprot IDs		P98095 Q86V58 Q9Y3V7	A0A024RDW8 P08572
PDB IDs			1LI1 5NAX 5NB2 6MPX
Enriched GO Terms of Interacting Partners?
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