MTIF3 and COL4A5

Data Source:
BioGRID (two hybrid)

		MTIF3	COL4A5
Description		mitochondrial translational initiation factor 3	collagen type IV alpha 5 chain
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GO Annotations	Cellular Component	Mitochondrion	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Ribosome Binding Ribosomal Small Subunit Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Ribosome Disassembly Mitochondrial Translational Initiation	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Pathways		Mitochondrial translation initiation	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Alport syndrome
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate change in renal transplantation (recipient effect) ( 30920136) Night sleep phenotypes ( 27126917) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603)
Interacting Genes		84 interacting genes: APOD BCL2L1 BMP10 BPIFA1 BRICD5 CABP7 CD47 CDIPT CDS2 CGRRF1 CLDND2 CLEC7A CMTM5 COL4A5 COQ8A CTXN3 CXCL9 CYBC1 CYP4F2 EPGN FBXO7 FETUB FXYD3 FXYD6-FXYD2 HSFX1 HSFX2 HTATIP2 ITGB2 JAGN1 LAPTM4B LAT LDLR LHFPL5 MAPK1 MGST3 MRFAP1 MS4A1 NAT8 NDRG4 ORMDL3 PAXIP1 PEA15 PLN PLP1 PRH1 RPRM SCD SELENOK SERP1 SERP2 SERTM1 SIAH1 SNX2 SPANXN2 STARD4 STATH STRIT1 STX3 STX6 THBD THSD7B TMED8 TMEM109 TMEM11 TMEM128 TMEM147 TMEM176A TMEM218 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM97 TRARG1 TSPAN33 TUFM UNC50 VAMP4 VEZT VKORC1L1 YIPF6 ZDHHC15 ZNF202	46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2
Entrez ID		219402	1287
HPRD ID		17609	02363
Ensembl ID		ENSG00000122033	ENSG00000188153
Uniprot IDs		Q9H2K0	A7MBN3 P29400 Q49AM6
PDB IDs		6NEQ 6NF8 6RW4 6RW5	5NAZ
Enriched GO Terms of Interacting Partners?
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