ACSL1 and NR3C2

Data Source:
BioGRID (two hybrid)

		ACSL1	NR3C2
Description		acyl-CoA synthetase long chain family member 1	nuclear receptor subfamily 3 group C member 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Chromatin Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Receptor Complex
	Molecular Function	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Arachidonate-CoA Ligase Activity Phytanate-CoA Ligase Activity Oleoyl-CoA Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Response To Nutrient Lipid Biosynthetic Process Positive Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Response To Organic Cyclic Compound Fatty Acid Transport Regulation Of Lipid Metabolic Process Triglyceride Biosynthetic Process Adiponectin-activated Signaling Pathway Response To Oleic Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Xenobiotic Catabolic Process Response To Drug Linoleic Acid Metabolic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs	HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors
Drugs		Adenosine phosphate ATP	Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
GWAS		Fulminant type 1 diabetes ( 30552108) Mean platelet volume ( 32888494) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 28566273 30054458 30297969)	Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet distribution width ( 32888494) Platelet reactivity in response to clopidogrel treatment ( 32472697) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)
Interacting Genes		1 interacting genes: NR3C2	20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I
Entrez ID		2180	4306
HPRD ID		01068	02991
Ensembl ID		ENSG00000151726	ENSG00000151623
Uniprot IDs		A8K9T3 B4E0R0 B7Z3Z9 E7EPM6 P33121	B0ZBF6 P08235
PDB IDs			1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG 6L88
Enriched GO Terms of Interacting Partners?
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