NR3C2 and HSPA4

Data Source:
HPRD (in vitro)

		NR3C2	HSPA4
Description		nuclear receptor subfamily 3 group C member 2	heat shock protein family A (Hsp70) member 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Receptor Complex	Nucleus Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding ATP Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Response To Unfolded Protein Protein Insertion Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors	Regulation of HSF1-mediated heat shock response
Drugs		Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate	Phenethyl Isothiocyanate
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
GWAS		Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet distribution width ( 32888494) Platelet reactivity in response to clopidogrel treatment ( 32472697) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)	Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549 31928498 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I	70 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		4306	3308
HPRD ID		02991	09025
Ensembl ID		ENSG00000151623	ENSG00000170606
Uniprot IDs		B0ZBF6 P08235	P34932
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG 6L88
Enriched GO Terms of Interacting Partners?
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