ALDH1A1 and POT1

Data Source:
BioGRID (two hybrid)

		ALDH1A1	POT1
Description		aldehyde dehydrogenase 1 family member A1	protection of telomeres 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Shelterin Complex
	Molecular Function	Retinal Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Benzaldehyde Dehydrogenase (NAD+) Activity NAD Binding	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding
	Biological Process	Retinoid Metabolic Process Ethanol Oxidation Cellular Aldehyde Metabolic Process Retinol Metabolic Process Positive Regulation Of GTPase Activity Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Negative Regulation Of Cold-induced Thermogenesis	Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Regulation Of DNA Helicase Activity Positive Regulation Of DNA Helicase Activity Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		RA biosynthesis pathway Fructose catabolism Ethanol oxidation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		NADH Vitamin A Tretinoin 1,4-Dithiothreitol
Diseases
GWAS		Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Sensorimotor dexterity ( 31596458)	Chronic lymphocytic leukemia ( 28165464 24292274) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 32109421 31171785) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors and depression ( 27622933)
Interacting Genes		4 interacting genes: ALDH2 BRCA1 NUPR1 POT1	166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		216	25913
HPRD ID		00001	07572
Ensembl ID		ENSG00000165092	ENSG00000128513
Uniprot IDs		P00352 V9HW83	A0A024R739 A8MTK3 Q5MJ33 Q9NUX5
PDB IDs		4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM	1XJV 3KJO 3KJP 5H65 5UN7
Enriched GO Terms of Interacting Partners?
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